CBD Bioavailability

CBD Bioavailability and Absorption: Nanometer Size Makes the Difference

The goal of any pharmaceutical should be to have a desired therapeutic effect, with minimal alternative effects from the drug or its by-products. By minimizing any other compounds required to transport and stabilize the drug, you essentially create a cleaner drug and limit the potential for confounding effects on the body. Furthermore, an ideal drug would have a reliable absorption into the body, as well as a predictable excretion, allowing us to know reliably how much drug is absorbed into our blood stream, where it can be distributed to tissues where it can deploy its effects.

CBD and Bioavailability

This second concept deals with bioavailability. Bioavailability is an important concept of any drug and is especially vital to CBD products. The bioavailability of CBD can vary greatly and depends on several variables. Perhaps the most important is the size of the molecule, where a smaller molecule is able to enter at higher rates versus a large molecule. For example, imagine your GI tract (where ingested drugs are absorbed) is a like a sieve your kids play with at the beach while panning for seashells. The size of the gaps in the sieve allow water and grains of sand thru while keeping shells, rocks, and whatever other debris is denied transport through the other side. This same principle happens in the intestinal walls, allowing smaller particles passage into the body for absorption into the blood stream, while large molecules pass by, only to be discarded and go unused.

CBD Particle Size and Absorption

Most of the drugs we take by mouth have rather poor absorption compared to drugs given by IV, and topical is even less. There a dozens of factors, most of which involve complex chemistry, that determines what molecules get through and ultimately absorbed. But as studies emerge, perhaps the most important difference that determines absorption of CBD is particle size.

Older generation CBD products generally had particle sizes from 200 to 5000 nanometers. Particles of this size are simply too large to pass through with high efficacy without help from other substrates. Furthermore, recall that CBD is recovered from hemp oil, and since our bodies are mostly water, many larger molecules require further binding with fats and oils to be transported to the blood stream.

Conversely, smaller molecules do not rely on more oils and fats for transport allowing not only better transport, but better stability and less taste-interference and side effects from by-products. This can be demonstrated when mixing CBD products with water. Older products that require other substrates become a yellow hue or may look milky while smaller CBD particles made with nanoemulsion will remain completely clear.

CBD Molecules Ideally < 100 Nanometers

In sum, a smaller CBD molecule, ideally < 100 nanometers, will allow a better absorbed, more stable, and therefore more effective and predictable effects on the body. The average size of a VALO Living CBD droplet is 70-90 nanometers – well under the < 100 nanometers threshold for maximum absorption and bioavailability. This size of CBD molecules in VALO Living CBD products allows for better absorption, more stability than other products using macroemulsion techniques. The science is clearly in support of smaller molecules by using nanoemulsion for CBD products and the markets are proving that this is the future direction of CBD products. When you purchase any of VALO Living CBD products, due to the industry leading technology that the products are produced with resulting in a nanometer size of 70-90 nanometers, you’re assured of having the best possible absorption and impact in your body.